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Head-to-head record and recent meetings.
Last 4 meetings
| 31 Oct 26 | S0–1 | Major League Soccer · St. Louis City home | details → |
| 2 Mar 26 | S0–2 | Major League Soccer · San Diego FC home | details → |
| 11 May 25 | S1–2 | Major League Soccer · St. Louis City home | details → |
| 2 Mar 25 | D0–0 | Major League Soccer · San Diego FC home | details → |
Scores shown from St. Louis City's perspective. From graded matches on record.